Immune Remodeling during Aging and the Clinical Significance of Immunonutrition in Healthy Aging

Aging is associated with changes in the immune system and gut microbiota. Immunosenescence may lead to a low-grade, sterile chronic inflammation multifactorial dynamic way, which plays critical role most age-related diseases. Age-related microbiota also shape inflammatory responses. Nutrition determinant of function Immunonutrion has been regarded as new strategy for disease prevention management, including many However, understanding cause-effect relationship required be more certain about immunonutrition supporting homeostasis its clinical relevance elderly individuals. Herein, we review remarkable quantitative qualitative during aging that contribute immunosenescence, inflammaging microbial dysbiosis, effects on late-life health conditions. Furthermore, discuss significance treatment diseases by systematically reviewing modulation clarify effect immunonutrition-based interventions healthy aging.